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Symbol Name ID |
Bmi1
Bmi1 polycomb ring finger oncogene MGI:88174 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Acute myeloid leukemia |
| Disease(s) Associated with BMI1 | |
| acute myeloid leukemia |
| Mouse Phenotypes | hematopoietic system phenotype |
decreased splenocyte proliferation |
abnormal thymus morphology |
thymus cortex hypoplasia |
small thymus |
thymus atrophy |
decreased thymocyte number |
abnormal thymus involution |
abnormal hemopoiesis |
abnormal definitive hematopoiesis |
decreased common myeloid progenitor cell number |
abnormal erythropoiesis |
decreased immature B cell number |
abnormal double-negative T cell morphology |
decreased double-positive T cell number |
anemia |
abnormal bone marrow cell morphology/development |
decreased bone marrow cell number |
increased common lymphocyte progenitor cell number |
decreased mature B cell number |
decreased B cell number |
decreased T cell number |
decreased lymphocyte cell number |
decreased myeloid cell number |
decreased hematopoietic cell number |
decreased hematopoietic stem cell number |
abnormal spleen morphology |
abnormal spleen red pulp morphology |
decreased spleen red pulp amount |
decreased spleen weight |
small spleen |
abnormal spleen white pulp morphology |
absent spleen germinal center |
abnormal spleen periarteriolar lymphoid sheath morphology |
decreased spleen white pulp amount |
decreased IgM level |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||
| Bmi1tm1Brn/Bmi1tm1Brn | |||||||||||||||||||||||||||||||||||||
| Bmi1tm1Sgon/Bmi1tm1Sgon Commd10Tg(Vav1-icre)A2Kio/? (conditional) |
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| Bmi1tm1Sgon/Bmi1tm1Sgon Gt(ROSA)26Sortm1(cre/ERT2)Tyj/? (conditional) |
* | ||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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